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Effects of GLP-1 Analogues and Agonists on the Gut Microbiota: A Systematic Review
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These have specificities for cationic residues (arginine and lysine) and aromatic residues respectively, so that most therapeutic proteins are vulnerable to attack by one or both of these enzymes
( Excellent discussion of the challenges of conducting clinical trials in obesity ) Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DC, le Roux CW, Violante Ortiz R, Jensen CB, Wilding JP, SCALE Obesity and Prediabetes NN8022-1839 Study Group
But it stops the re-injury cycle so that other treatments can actually work
